Low stage laser remedy for burning mouth syndrome


Burning mouth syndrome is a fancy persistent orofacial ache situation. The prevalence of burning mouth syndrome has been reported to vary from 0.7% to fifteen% in numerous settings (Dental Elf – 2nd July 2021). A current evaluate by Alvarenga-Brant et al (Dental Elf – 21st Oct 2022) indicated that clonazepam, low-level laser remedy also called photobiomodulation remedy (PBMT) and pregabalin had an affect on ache ranges.

The goal of this evaluate was to judge the impact of low-level laser remedy (LLLT) on burning ache, high quality of life, and damaging feelings in sufferers with burning mouth syndrome (BMS).


A protocol was registered on the PROSPERO database. Searches have been carried out within the PubMed, Embase, Cumulative Index of Nursing and Allied Well being Literature (CINAHL), the Cochrane Library, Net of Science, and Scopus databases. English language randomised managed trials (RCTs) of LLLT (600 – 1100nm) for the remedy of BMS have been thought of. Three reviewers independently screened research with information extraction being carried out by a single reviewer and checked by a second reviewer. Research high quality was assessed utilizing the Cochrane danger of bias software (RoB2). Outcomes have been offered because the weighted imply distinction (WMD) or standardised imply distinction (SMD) with 95% confidence intervals.


  • 14 research met the inclusion standards.
  • 9 RCTs involving a complete of 444 sufferers (229 with BMS and 215 controls contributed to the quantitative evaluation.
  • The laser wavelength ranged from 630 to 1064 nm, energy (30 mW to 4 W), and irradiance (0.003 to 4 W/cm2).
  • 2 RCTs have been thought of to be at low danger of bias, 5 RCTs at excessive danger of bias and seven RCTs at unclear danger.
  • Meta-analysis confirmed: –
    • LLLT was considerably more practical than sham LLLT in lowering ache depth SMD = -0.92 (95percentCI: -1.38 to -0.46) [10 studies].
    • LLLT was barely more practical than clonazepam (SMD = -0.47, 95% CI: -1.17 to 0.23) [1 study].
  • Subgroup evaluation indicated that LLLT decreased burning ache depth when the intervention:-
    • period was >4 weeks SMD = -1.12 (95percentCI: -1.58 to -0.66) [5 studies].
    • frequency was < or=2 instances per week SMD= -1.22 (95percentCI: -1.59 to -0.85) [6 studies].
  • Evaluation suggests optimistic modifications in
    • high quality of life (assessed utilizing the Oral Well being Impression Profile-14), SMD = 0.01 (95percentCI: -0.58 to 0.60) and
    • damaging feelings (evaluated utilizing the Hospital Anxiousness and Despair Scale; SMD = -0.12, 95percentCI: -0.54 to 0.30), however these results weren’t statistically important.


The authors concluded: –

Low-level laser remedy may scale back burning ache in sufferers with burning mouth syndrome and have a optimistic affect on the standard of life and nervousness signs, with out critical negative effects, indicating that it might be an efficient remedy for burning mouth syndrome. Nonetheless, given the low methodological high quality of the chosen research, our outcomes must be interpreted with warning. An extended-term course of intervention, a bigger pattern dimension, and a multidisciplinary intervention design are urgently wanted.


A protocol for this evaluate was registered on PROSPERO though the query being addressed was broader being for bodily therapies for the remedy of BMS slightly than being particularly for LLLT. A broad vary of databases have been searched though the restriction to these revealed in English could have excluded some related research. The included research are small to reasonable in dimension and number of lasers are used utilising completely different frequencies, energy, and irradiance in addition to software period and schedules. Consequently, whereas the findings counsel optimistic outcomes with LLLT use there must be interpreted cautiously. A famous by the authors of their conclusions extra top quality properly reported trials of applicable dimension and period are wanted to correctly make clear any advantages for using LLLT in BMS sufferers. The routine use of internationally agreed frequent final result measures (COMET) would even be useful for future comparisons.


Main Paper

Lu C, Yang C, Li X, Du G, Zhou X, Luo W, Du Q, Tang G. Results of low-level laser remedy on burning ache and high quality of life in sufferers with burning mouth syndrome: a scientific evaluate and meta-analysis. BMC Oral Well being. 2023 Oct 9;23(1):734. doi: 10.1186/s12903-023-03441-w. PMID: 37814265; PMCID: PMC10561515.

Assessment protocol in PROSPERO

Different references

Dental Elf – 2nd July 2012

Prevalence of burning mouth syndrome

Dental Elf – 21st Oct 2022

Burning mouth syndrome remedies – community meta-analysis

Dental Elf – Burning Mouth Syndrome Blogs

Image Credit

Photograph by engin akyurt on Unsplash




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