Prenatal vitamin D and enamel defects


Vitamin D is a vital nutrient important for calcium and phosphate metabolism contributing to the mineralisation of tooth and bones. Various genetic and environmental components affect the event and maturation of enamel and Vitamin D might play an important function on this.

The intention of this overview was to guage the potential impression of prenatal Vitamin D ranges on enamel defects and tooth erosion.


The overview was registered on the Open Science Framework (OSF) platform. Searches have been carried out within the PubMed, Scopus, and Net of Science databases. English language research of the impression of Vitamin D on enamel defects and tooth erosion in youngsters after prenatal measurement of Vitamin D ranges the place Vitamin D evaluation strategies have been clearly described have been thought of. Research have been evaluated utilizing the High quality Evaluation Device for Observational Cohort and Cross-Sectional Research. A story abstract of the findings was introduced.


  • 7 research (2 randomised managed trials, 2 potential & 3 retrospective cohorts) involving a complete of 6978 individuals have been included.
  • The included research have been printed between 2014 and 2022.
  • All included research have been rated nearly as good or glorious.
  • Pattern sizes ranged from 29 to 4750.
  • Vitamin D supplementation practices assorted throughout the research.
  • Kids’s age at examination assorted from 3.6 to six.6 years.
  • 4 research reported a big affiliation between prenatal Vitamin D insufficiency and an elevated threat of enamel defects.
  • 1 examine reported that top Vitamin D ranges had a protecting impact towards Hypomineralised Second Major Molars (HSPM) and Molar Incisor Hypomineralisation (MIH).


The authors concluded: –

..overview means that prenatal Vitamin D ranges and supplementation may need a big impression on youngsters’s enamel defects and tooth erosion. Thus, satisfactory prenatal Vitamin D might be an vital element of preventive dental well being methods. However, because of the important heterogeneity among the many chosen research and the potential impression of confounding components, additional analysis is required to substantiate these findings. Furthermore, the extent and consistency of the noticed results differ between research, with some displaying no affiliation between prenatal Vitamin D and dental outcomes. This variance warrants additional analysis to elucidate the underlying mechanisms and to determine definitive conclusions.


Whereas this overview is registered on the OSF platform solely the overview summary was obtainable (accessed 15th Oct). Three main databases have been searched, and the standard of included research have been assessed and whereas the authors point out that the PRISMA tips have been adopted there’s a lack of methodological element in paper. Solely 7 papers have been included and the restriction to English language research solely signifies that some related research might have been excluded. Solely a story abstract was introduced because the research assorted in relation to the examine designs, Vitamin D evaluation strategies, enamel defect evaluation, and demographic traits of the populations studied. A majority of the included research demonstrated an affiliation between the Vitamin D ranges and enamel defects the findings must be interpreted very cautiously.


Major Paper  

Tapalaga G, Bumbu BA, Reddy SR, Vutukuru SD, Nalla A, Bratosin F, Fericean RM, Dumitru C, Crisan DC, Nicolae N, Luca MM. The Influence of Prenatal Vitamin D on Enamel Defects and Tooth Erosion: A Systematic Evaluation. Vitamins. 2023 Sep 5;15(18):3863. doi: 10.3390/nu15183863. PMID: 37764647; PMCID: PMC10537257.

Evaluation registration on the Open Science Framework (OSF) platform 

Different references

Dental Elf – 3rd Feb 2016

Vitamin D standing and caries related?

Dental Elf – 2nd Could 2022

Hypomineralised second major molars and prenatal, perinatal and postnatal exposures




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