Vitamin D and dental caries threat in youngsters


Vitamin D performs an essential function within the formation and growth of tooth and bone with a hyperlink between vitamin D ranges and caries being reported round 100 years in the past (Mellanby, 1928). Quite a lot of potential mechanisms for the impression on dental well being have been hypothesised however the relationship between caries and vitamin D is ambiguous.

The purpose of this overview was to guage the affiliation between the next expertise of dental caries and decrease serum vitamin D ranges in youngsters.


Searches have been carried out within the Cochrane Library, PubMed, Embase, and Net of Science databases with no language restrictions. Cohort, case-control, and cross-sectional research investigating the affiliation between vitamin D degree and dental caries in youngsters have been thought-about. Two reviewers independently searched and chosen research and extracted knowledge. High quality of the cohort and case-control research was assessed utilizing the Newcastle-Ottawa Scale (NOS) and the Joanna Briggs Institute (JBI) standards used for the cross-sectional research. Relative threat (RR) and 95% confidence intervals (CIs) have been calculated, and meta-analyses carried out.


  • 13 research (5 cohort, 5 cross-sectional, 3 case-control) involving a complete of 19,205 sufferers have been included.
  • Pattern sizes ranged from 38 to five,545 sufferers.
  • The standard of all 13 research have been rated as excessive.
  • Meta-analyses confirmed the next threat of dental caries for sufferers with vitamin D deficiency (see desk under).
Evaluation No. of research Relative threat (95percentCI)
Unadjusted 13 1.22 (1.18 – 1.25)
Adjusted for confounders 9 1.16 (1.10 – 1.22)
Cohort research solely 5 1.62 (1.51 – 1.74)
Cross-sectional solely 5 1.19 (1.14 – 1.24)
Case-control research solely 3 1.05 (1.00 – 1.09)
Everlasting dentition solely 2 1.28 (1.21 – 1.35)
Major dentition solely 6 1.68 (1.57 – 1.79)
Blended dentition 4 1.08 (1.04 – 1.12)


The authors concluded: –

… dental caries is negatively related to 25(OH)D ranges in kids. To enhance youngsters’s dental well being, it is very important guarantee ample consumption of 25 (OH) D throughout childhood. Healthcare professionals ought to be conscious that prenatal vitamin and childish childhood eating regimen can have an effect on the incidence of dental caries in youngsters.


The authors searched 4 main databases with no language restrictions figuring out 13 observational research. The findings recommend larger ranges in caries in sufferers with vitamin D deficiencies. Nonetheless, the research are heterogeneous with included research utilizing completely different strategies of measure caries there’s additionally variation within the timing of the vitamin D measurements. Whereas numerous analyses have been undertaken to take into consideration dentition, examine sort and a few confounders solely toothbrushing an socio-economic standing have been talked about within the paper.  One of many Schroth papers included on this overview thought-about by us in 2016 (Dental Elf – 3rd Feb 2016) included toothbrushing and dental visits. Future research ought to contemplate an agreed variety of widespread confounders for caries.  Bigger potential cohort research with extra common measurement of vitamin D ranges can be required to evaluate the power of the affiliation between vitamin D and caries.


Major Paper  

Li Z, Wei X, Shao Z, Liu H, Bai S. Correlation between vitamin D ranges in serum and the danger of dental caries in youngsters: a scientific overview and meta-analysis. BMC Oral Well being. 2023 Oct 19;23(1):768. doi: 10.1186/s12903-023-03422-z. PMID: 37858104; PMCID: PMC10585927.

Different references

Mellanby M, Pattison CL. The motion of vitamin D in stopping the unfold and selling the arrest of caries in youngsters. Br Med J. 1928 Dec 15;2(3545):1079-82. doi: 10.1136/bmj.2.3545.1079. PMID: 20774325; PMCID: PMC2456958.

Dental Elf – 16th Oct 2023

Prenatal vitamin D and enamel defects

Dental Elf – 3rd Feb 2016

Vitamin D standing and caries related?

Dental Elf – 20th Nov 2012

Assessment revisits previous proof linking vitamin D and dental caries and suggests there could also be a profit




Supply hyperlink
We will be happy to hear your thoughts

Leave a reply