Dental caries and genetics – is there a hyperlink?


Dental caries one of many world’s commonest power illnesses has been estimated to have an effect on virtually 50% of the world’s inhabitants. It’s a sugar-dependent biofilm illness that’s modulated by a number of components with environmental and host components affecting caries danger. Nevertheless, there’s variation in illness onset and prevalence amongst people uncovered to the identical danger components which will point out a genetic affect though no consensus. As monozygotic twins have equivalent genetic codes, and dizygotic twins share half of their genes using comparative research between them have been used to estimate the participation of genotype and setting within the incidence of dental caries.

The goal of this overview was to evaluate the settlement of dental caries expertise between monozygotic (MZ) and dizygotic twins (DZ).


The overview protocol was registered on the PROSPERO database. Searches had been performed on the Embase, Medline/PubMed, Scopus, Google Scholar (first 300 articles) and OpenGrey databases. This was supplemented by hand searches of the Journals, Archives of Oral Biology, Caries Analysis, Group Dentistry and Oral Epidemiology, Worldwide Journal of Paediatric Dentistry, Journal of Dental Analysis and Paediatric Dentistry for the final 5 years. Observational research (cross-sectional, case- management, and potential and retrospective cohorts) that in contrast dental caries settlement between dentate MZ and DZ twins of all age teams had been thought-about. Two reviewers independently chosen research extracted knowledge and assessed danger of bias utilizing the Joanna Briggs Institute checklists (JBI-CAT). Odds Ratio (OR) and 95% confidence intervals had been calculated for every examine and meta-analyses performed. The Grading of Suggestions Evaluation, Improvement, and Analysis (GRADE) scale was used to evaluate the knowledge of proof.


  • 19 research (11 cross-sectional,7 longitudinal, 1 case-control) had been included.
  • Research had been revealed between 1958 – 2020 from 11 international locations.
  • The research concerned a complete of 42,536 folks aged between 18 months to 97 years of age.
  • 21% of research had been thought-about to be at excessive danger of bias, 47.7% at average danger and 31.6% at low danger.
  • 6 research contributed to the meta-analyses.
  • Meta-analysis for normal settlement of dental caries confirmed a better change of settlement between MZ twins for: –
    • major dentition, OR = 68 (95percentCI: 1.23 to 26.35) [1 study].
    • each dentitions, OR = 6.58 (95percentCI: 1.55 to 27.88) [4 studies].
    • Total, OR = 5.94 (95percentCI: 2.00 to 17.57) [ 5 studies].
  • Two research evaluated settlement of DMF one within the major and one within the everlasting dentition No distinction was seen between MZ and DZ twins, OR = 86 (95percentCI: 0.25 to 32.79).
  • The knowledge of proof was assessed as very low.


The authors concluded: –

with very low certainty of the proof, there was a better settlement of dental caries between monozygotic twins than in dizygotic twins, suggesting the affect of genetics on the event of the illness.


The authors registered their protocol with the PROSPERO database and searched a superb reange of databases to determine related research. In a change from the protocol, they used the JBI instruments to evaluate danger of bias fairly than the Company for Healthcare Analysis and High quality (AHRQ) scale for cross-sectional research and the Newcastle-Ottawa Scale. Whereas 31% of the included research had been thought-about to be at low danger of bias all 19 of the included research didn’t tackle considered one of extra of the eight JBI guidelines questions.  Solely 7 of the included research recognized potential confounders with only one examine controlling for confounders. The authors additionally raised different issues associated to the first research in relation to lack of particulars on the collection of individuals standards for assessing zygosity and measurement of caries. Consequently, though the evaluation is suggestive of a genetic affect the knowledge of proof may be very low so the findings must be interpreted very cautiously.


Main Paper  

Dos Anjos AMC, Moura de Lima MD, Muniz FWMG, Lima CCB, Moura LFAD, Rösing CK, de Moura MS. Is there an affiliation between dental caries and genetics? Systematic overview and meta-analysis of research with twins. J Dent. 2023 Aug;135:104586. doi: 10.1016/j.jdent.2023.104586. Epub 2023 Jun 18. PMID: 37339689.

Evaluation protocol on PROSPERO

Different references

Dental Elf – 11th Jun 2021


Dental Elf – 9th Mar 2015


Image Credit

Photograph by Keisha Montfleury on Unsplash




Supply hyperlink
We will be happy to hear your thoughts

Leave a reply